Update on the treatment of calcinosis in dermatomyositis.

نویسندگان

  • Samuel Katsuyuki Shinjo
  • Fernando Henrique Carlos de Souza
چکیده

Calcinosis is a connective tissue disorder classified into the following four types: metastatic; idiopathic; iatrogenic and dystrophic. Dystrophic calcinosis can occur, for example, in dermatomyositis, mainly in juvenile dermatomyositis, and is characterized by an abnormal deposition of calcium salts in affected skin, subcutaneous tissues, and muscles or tendons, with normal serum levels of calcium and phosphate. The treatment of calcinosis in dermatomyositis remains a challenge, with few descriptions in the literature of low scientific evidence. So far, no therapy has proved to be highly effective in the combat and resolution of that comorbidity. The present study discusses the concept of calcinosis, particularly in dermatomyositis, as well as its treatment described in the literature.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Juvenile dermatomyositis: review and update of the pathogenesis and treatment.

Juvenile dermatomyositis (JDM) is an autoimmune disease characterized by systemic vasculopathy. Its main manifestations include symmetrical proximal muscle weakness, elevated serum muscle enzymes and cutaneous lesions, among which the heliotrope and Gottron's papules are pathognomonic. Early recognition and prompt therapy allow better prognosis and prevent the development of calcinosis. Althoug...

متن کامل

PReS-FINAL-2275: Improvement of calcinosis cutis with intravenous pamidronate in a 2-year-old girl with progressive widespread skin calcification of unknown origin

Introduction Pathologic calcification occurs in up to 40% of children with juvenile dermatomyositis and can develop within several months even in successfully treated patients. Other differential diagnoses of calcinosis cutis in children are rare. There is no generally accepted standard treatment of calcinosis. We report on a 2-year-old previously healthy girl, the 2 child of non-consanguineous...

متن کامل

Severe calcinosis cutis with cutaneous ulceration in juvenile dermatomyositis.

BACKGROUND Calcinosis cutis is usually seen in long standing and untreated cases of juvenile dermatomyositis. CASE CHARACTERISTICS 7-year-old girl with severe calcinosis cutis who developed cutaneous ulceration, rash and myopathy. OBSERVATION Myopathic changes in EMG, muscle edema in MRI, elevated muscle enzymes and Jo-1 positive antibodies. OUTCOME Treatment with prednisolone and methotr...

متن کامل

Therapy of calcinosis universalis complicating adult dermatomyositis.

Although frequent in juvenile dermatomyositis, calcinosis is a rare finding in adult dermatomyositis. It has been associated with disease activity and delayed treatment. It is more common in later phases of the disease, in sites under chronic stress and trauma. Calcinosis has been associated with inflammation but information about its pathogeny continues to evolve as we learn more about the und...

متن کامل

Treatment of calcinosis with biphosphonates in juvenile dermatomyositis

Juvenile dermatomyositis (JDM) is a multisystem disease that is characterized by nonsuppurative inflammation of striated muscle and skin. Dystrophic calcification occurs in up to 40% of children We present our treatment approach in four JDM patients with calcinosis. Four female patients (median age 8.5 years, range 6–14) had been diagnosed as JDM in our center. Two of them presented with severe...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Revista brasileira de reumatologia

دوره 53 2  شماره 

صفحات  -

تاریخ انتشار 2013